Molecular mechanisms involved in intestinal iron absorption
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منابع مشابه
TOPIC HIGHLIGHT Molecular mechanisms involved in intestinal iron absorption
Iron is an essential trace metal in the human diet due to its obligate role in a number of metabolic processes. In the diet, iron is present in a number of different forms, generally described as haem (from haemoglobin and myoglobin in animal tissue) and non-haem iron (including ferric oxides and salts, ferritin and lactoferrin). This review describes the molecular mechanisms that co-ordinate t...
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Recent studies (1-3) have indicated that gastrointestinal absorption of iron is a more complicated process than was initially postulated (4, 5). For example, several investigators have proposed as the result of studies in rats (2, 3), dogs (6), and humans (7) that iron absorption involves at least 2 steps: 1) mucosal uptake of iron from the intestinal lumen and 2) transfer of iron from mucosal ...
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Hereditary hemochromatosis (HHC) is one of the most frequent genetic disorders in humans. In healthy individuals, absorption of iron in the intestine is tightly regulated by cells with the highest iron demand, in particular erythroid precursors. Cloning of intestinal iron transporter proteins provided new insight into mechanisms and regulation of intestinal iron absorption. The aim of this stud...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2007
ISSN: 1007-9327
DOI: 10.3748/wjg.v13.i35.4716